Health Condition 1: F102- Alcohol dependence Health Condition 2: H- Substance Abuse Treatment
Conditions
Interventions
Intervention1: Odor simulated virtual reality: A sub-cohort from Study 1 will undergo a randomized trial using virtual reality (VR) therapy with pleasant odor exposure for two weeks. A systematic odor
Sponsors
National Brain Research Center
Eligibility
Inclusion criteria
Inclusion criteria: To be eligible to participate in this study, an individual must meet all the following criteria: 1.Individuals between 18 to 65 years of age. 2.Individuals with a diagnosis of AUD (for the AUD cohort) OR without a diagnosis of AUD (for the healthy volunteer cohort). 3. Able to provide their own consent.
Exclusion criteria
Exclusion criteria: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Currently have an uncontrolled medical disorder (i.e., gastrointestinal, endocrine, cardiac, psychiatric). 2. Any history of chronic rhinitis, eating disorder (including binge eating), acute or chronic upper respiratory infection, allergic rhinitis, nasal polyps, or daily use of nasal sprays. 3. Altered cranial nerves associated with taste and olfaction identified by neurological evaluation during physical exam. 4. Positive pregnancy test, currently pregnant or breastfeeding. 5. Hypoglycemic drug intake. 6. Current cold/flu symptoms or temporary loss of smell 7. Persistent loss of smell due to COVID-19.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| olfactory scores, cognition, craving and physiological responsesTimepoint: Pretherapy, Post 1 week therapy, Post 2 week therapy and Post 3 week therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Neural outcomes including brain activity on odor cue task, brain connectivity patterns, metabolic profiles in brain regions specific to reward, structural brain regions.Timepoint: Pretherapy, Post 1 week therapy, Post 2 week therapy & Post 3 week therapy. | — |
Countries
India
Contacts
Public ContactDr Khushbu Agarwal
National Brain Research Centre
Outcome results
None listed