Health Condition 1: H179- Unspecified corneal scar and opacity
Conditions
Interventions
Intervention1: Systemic Mycophenolate Mofetil: 1g twice daily for 1 month followed by 500mg twice daily 11 months
Control Intervention1: Topical Tacrolimus 0.1% eye ointment: 4 times daily for 1 month
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing penetrating keratoplasty with either more than equal to 2 quadrants of deep stromal neovascularization (more than 2 mm) , or Repeat corneal grafts
Exclusion criteria
Exclusion criteria: Patients with uncontrolled glaucoma, active microbial keratitis or limbal stem cell deficiency, pregnant and lactating females, patients with a history of malignancy, patients having uncontrolled diabetes or hypertension, patients with systemic infections , patients with gastrointestinal diseases or abnormal hematologic, hepatic or renal function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial graft rejectionTimepoint: Between 2 weeks of keratoplasty till the last follow up visit (atleast 6 months, 12 months desirable) | — |
Secondary
| Measure | Time frame |
|---|---|
| Graft survivalTimepoint: 6months , 12 months;Proportion of reversible graft rejection episodes.Timepoint: ;Rate of systemic and ocular adverse eventsTimepoint: ;Best corrected visual acuityTimepoint: Last follow up;BAASIS questionnaireTimepoint: 21 days, 3 most, 6 months, 12 months | — |
Countries
India
Contacts
Public ContactAashima Sachdeva
Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS New Delhi
Outcome results
None listed