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Effect of Anaesthesia with Propofol on heart function in people with high blood pressure

Effect of Induction of General Anaesthesia with Propofol on Ventriculo-arterial coupling dynamics in hypertensive patients - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/089822
Enrollment
63
Registered
2025-06-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10-I16- Hypertensive diseases

Interventions

Intervention1: Nil: Nil

Sponsors

Department of Anaesthesiology, Pain Medicine and Critical Care AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age more than 18 years 2. Known hypertensive disorder 3. Scheduled to undergo elective, non cardiac procedures under general anaesthesia

Exclusion criteria

Exclusion criteria: 1. Uncontrolled hypertension - SBP more than 180 mmHg or DBP more than 110 mmHg 2. Known cases of coronary artery disease or congestive heart failure, significant structural heart disease, aortic disease, pacemaker 3. Arrhythmias 4. Left ventricular ejection fraction less than 35-40% 5. Hypersenstivity to Propofol emulsion or any of its constituents 6. Extremes of BMI : less than 18 or more than 30 7. Poor ECHO window

Design outcomes

Primary

MeasureTime frame
Pre and post-induction difference in Ventriculo-arterial coupling (VAC) ratioTimepoint: T1 - Pre induction T2 - Pre intubation (post induction of anaesthesia) T3 - Post intubation (5 minutes post induction) T4 - 15 minutes post induction

Secondary

MeasureTime frame
Pre-induction vs Post-induction difference in arterial elastance (Ea), end systolic elastance (Ees), left ventricular ejection fraction, stroke volume, heart rate, cardiac index, systemic vascular resistance indexTimepoint: T1 - Pre induction T2 - Pre intubation (post induction of anaesthesia) T3 - Post intubation (5 minutes post induction) T4 - 15 minutes post induction

Countries

India

Contacts

Public ContactDr Priyankar Kumar Datta

AIIMS, New Delhi

priyankar.k.datta@gmail.com9830771756

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026