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Assessment of breathing muscle weakness in head injury patients using ultrasound.

Ultrasound-based diaphragm muscle weakness assessment and its impact on weaning duration in traumatic brain injury patients requiring invasive ventilation : A prospective observational study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/089821
Enrollment
88
Registered
2025-06-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S062- Diffuse traumatic brain injury

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Intervention4: Nil: Nil

Sponsors

Postgraduate Institute of Medical Education and Research Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of either sex between 18 to 65 yrs of age with isolated traumatic brain injury admitted to the neurotrauma ICU who will be mechanically ventilated

Exclusion criteria

Exclusion criteria: Pregnancy, body mass index greater than 35 kg per meter square, pre existing neuromuscular disease or use of corticosteroids or antibiotic such as aminoglycosides, chronic renal insufficiency, pre existing lung injury, autoimmune diseases, bone and spine fractures, skin lesions at evaluation site, clinical suspicion of brain death, use of neuromuscular blockers during ICU stay.

Design outcomes

Primary

MeasureTime frame
Assessment of correlation between ultrasound based diaphragm thickness fraction (DTF) at 72 hours and weaning duration in TBI patients requiring mechanical ventilationTimepoint: At 72 hours—

Secondary

MeasureTime frame
Assessment of the prevalence and progression of diaphragm weakness bt measuring diaphragmatic thickness fraction (DTF) and diaphragmatic excursion (DE) on day of ICU admission and then serially on day 3,5 and 7 or at discharge whichever is early.Timepoint: On day 0,3,5,7 or at discharge, whichever is early;Assessment of peripheral muscle thickness in quadriceps femoris and biceps brachii muscle on the day of ICU admission and then serially on day 3,5 and 7 or at discharge whichever is earlyTimepoint: On day 0,3,5,7 or at discharge, whichever is early;Correlation between trends of USG based diaphragmatic thickness and USG based peripheral muscle thicknessTimepoint: ;Duration of weaning from ventilator- defined as time taken from the start of weaning trials to successful removal from mechanical ventilation for 24 hours.Timepoint: ;Duration of ICU and hospital stayTimepoint:—

Countries

India

Contacts

Public ContactDr Shalvi Mahajan

Postgraduate Institute of Medical Education and Research

guptaparul35@gmail.com9015465811

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026