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Using Personalized Blood Flow Monitoring During Long Heart Surgeries to Improve Recovery After Surgery.

Goal-Directed Perfusion in Prolonged Cardiac Surgery with Cardiopulmonary Bypass: Implications on postoperative Outcomes. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/089797
Enrollment
173
Registered
2025-06-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I089- Rheumatic multiple valve disease,unspecified Health Condition 2: I349- Nonrheumatic mitral valve disorder, unspecified Health Condition 3: I359- Nonrheumatic aortic valve disorder, unspecified Health Condition 4: I369- Nonrheumatic tricuspid valve disorder, unspecified Health Condition 5: I379- Nonrheumatic pulmonary valve disorder, unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Control Intervention1: Conventional Perfusion Strategies (from published historical studies): Comparison will be made with outcome data from published s
only outcome metrics will be used for reference

Sponsors

Dr Yasmeen Masood Rowther Raheem
Lead Sponsor
Dr Salome Jeyabalan
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Elective, primary cardiac surgery: Valve replacements or valve repairs 2. Complete CPB and cardioplegic arrest, with an expected CPB duration>90 minutes and lowest core temperature during CPB - 28 C

Exclusion criteria

Exclusion criteria: 1.Patient refusal for study 2.Emergent surgeries. 3.Minimally invasive surgeries. 4.Procedures requiring deep hypothermic circulatory arrest 5.Coagulation disorder 6.Severe chronic renal failure (receipt of dialysis or a serum creatinine level >3.0 mg/dl), 7.Liver dysfunction (elevated liver enzymes >3 SD) 8.Previous cerebrovascular accident 9.Obesity (BMI >30Kg/m 2)

Design outcomes

Primary

MeasureTime frame
Decline in postoperative renal functionTimepoint: 24 hours post-surgery—

Secondary

MeasureTime frame
Liver Dysfunction (AHI Acute Hepatic Injury)Timepoint: First postoperative ALT value within 24 hours;Inotrope requirementTimepoint: Measured 6-hourly for the first 24 hours after ICU admission;Prolonged ICU stayTimepoint: ICU stay more than 48 hours;Ventilation Duration (Weaning Time)Timepoint: From ICU admission until extubation. (prolonged if more than 24 hours postoperatively);Blood Transfusion RequirementsTimepoint: Intraoperative and postoperative period (0 24 hrs);Hospital MortalityTimepoint: From surgery until discharge;Requirement of Mechanical Circulatory Support or Other Adverse EventsTimepoint: From surgery until discharge—

Countries

India

Contacts

Public ContactYasmeen Masood Rowther Raheem

Narayana health city, Bengaluru

salome.jeyabalan@gmail.com9742779888

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026