Health Condition 1: N289- Disorder of kidney and ureter, unspecified Health Condition 2: N288- Other specified disorders of kidney and ureter
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Academic
Eligibility
Inclusion criteria
Inclusion criteria: Adults aged 18 years and above who have undergone kidney transplantation will be included in the study. Eligible participants include recipients of either deceased or live donor kidney transplants who are receiving triple immunosuppression therapy consisting of corticosteroids tacrolimus and mycophenolate with or without induction therapy. Patients must have stable graft function at the time of enrolment no active malignancy at the time of transplantation and must be willing to provide informed consent and comply with the study follow-ups.
Exclusion criteria
Exclusion criteria: Patients will be excluded if they have delayed graft function persisting beyond 30 days post transplant major rejection episodes or impending graft failure occurring within 1 month post transplant presence of severe metabolic disorders or terminal illness history of recurrent life threatening infections requiring hospitalization within 1 month post transplant pre transplant BMI exceeding 30 multi organ transplantation previous history of graft loss pregnancy or plans for pregnancy within the study follow up period history of severe osteoporosis or prior fractures due to metabolic bone disease and chronic steroid therapy for non transplant related conditions within 3 months of transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is to study the longitudinal changes in body composition in post renal transplant recipients by assessment of fat mass lean mass and bone health using DEXA scans at baseline which is 30 days post transplant and over a period of two years.Timepoint: 1,6,12,24 months of post transplant follow up period | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess the correlation of DEXA with BMI, WHC, neck circumference and skinfold thickness.Timepoint: 1,6,12,24 months of post transplant follow up period;Investigate the association between body composition changes and graft function, considering factors like infection episodes, acute rejection, and drug toxicity.Timepoint: 1,6,12,24 months of post transplant follow up period;Evaluate the impact of obesity on metabolic syndrome in renal transplant recipients Timepoint: 1,6,12,24 months of post transplant follow up period | — |
Countries
India
Contacts
Public ContactSree Bhushan Raju
Nizams Institute of Medical Sciences
Outcome results
None listed