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A Study Comparing how well Two types of Blood Clot treatments help heal Bone Loss between teeth One with a medicine to reduce bleeding (Tranexamic Acid) and one without and How a healing protein (PDGF-BB) is released during the First days of recovery.

Evaluation of the Clinical And Radiographic Efficacy And Safety of Platelet Rich Fibrin Integrated with Tranexamic Acid versus Platelet Rich Fibrin alone in the Management of Interproximal Intrabony Alveolar Defects : A Randomized Controlled Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089768
Enrollment
72
Registered
2025-06-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: OFD with PRF WITH Tranexamic acid placement: Extraoral antisepsis is performed with 5 PERCENT povidone iodine solution and 0.2 PERCENT chlorhexidine digluconate rinse. All surgical pro

Sponsors

Government Dental College And Research institute Bangalore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Age 18 to 60 years of both gender. 2 Subjects with diagnosis of periodontitis Stage III or IV. 3 Full mouth plaque score 15 Percent PI 1.5 & full mouth bleeding score FMBS 15 percent at the time of enrolment. 4 Subjects in good general health with normal Platelet count ASA I 5 Etiological periodontal therapy completed at least 3 months prior to the screening. 6 Presence of one natural tooth having a vertical defect with residual probing depth PD 5 mm and radiographic intrabony component 3mm and radiographic angle of defect between 25 to 45 degree.

Exclusion criteria

Exclusion criteria: 1 Grade C periodontitis. 2 Smoking habits. 3 Pregnancy and lactation. 4 History of periodontal surgery or prosthetic restorations at the experimental teeth. 5 Mobility of teeth greater than Grade II. 6 Non vital teeth or occlusal trauma. 7 Known Allergy from Tranexamic acid.

Design outcomes

Primary

MeasureTime frame
Radiographic bone fill at 12 months.Timepoint: Radiographic bone fill at 12 months.—

Secondary

MeasureTime frame
Changes in Clinical Parameters : Change in Probing depth , Gain in Clinical Attachment levels, Gingival Marginal levels as assessed at 3 , 6 ,9 & 12 months.Timepoint: At 3 , 6 ,9 & 12 months.—

Countries

India

Contacts

Public ContactDr Smitha K

Government dental college and research institute

periosmitha@gmail.com9449630572

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026