Do Probiotic Lozenges and Toothpaste Lower Cavity-Causing Bacteria in Braces Users? A Clinical Trial

Comparative Efficacy of Probiotic Lozenges and Probiotic Toothpaste on the Reduction of Salivary Streptococcus mutans in Orthodontic Patients: A Randomized Clinical Trial - PROSMORT Trial Probiotic intervention on Salivary Mutans in Orthodontic patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089735

Enrollment

Registered

2025-06-27

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: -

Interventions

Intervention1: probiotic lozenges: samples will be given probiotic lozenge and saliva sample will be collected to check salivary streptococcus mutans count Intervention2: probiotic toothpaste: samples

Eligibility

Inclusion criteria

Inclusion criteria: Orthodontic treatment with MBT. Permanent dentition.

Exclusion criteria

Exclusion criteria: 1.Patients consuming tobacco in any form (smoking or chewing). 2. Systemic antibiotic consumption within 4 weeks. 3. Topical fluoride treatment within 4 weeks. 4. Active carious lesion 5. Periodontal problem 6. Individuals with habitual use of probiotics products not related to the study.

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of probiotic lozenges and probiotic toothpaste in reducing level of salivary Streptococcus mutans in patient undergoing orthodontic treatment. Timepoint: 8 months	—

Secondary

Measure	Time frame
To evaluate level of Streptococcus mutans in saliva without consuming probiotic products in patients undergoing orthodontic treatment.Timepoint: 8 months	—

Countries

India

Contacts

Public ContactDr Riya Gala

maharashtra institute of dental sciences and research, latur maharashtra -413512, india

galariya25@gmail.com9004894036

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026