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Comparing Bone Healing With and Without a Growth Protein in Gum Disease Treatment

Evaluating the effect of TGF beta 1 with bone graft and bone graft alone in the treatment of intrabony defect A clinico radiographic study - nil

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089717
Enrollment
40
Registered
2025-06-27
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: bone graft with tgf beta 1: To assess the clinical and radiographic outcomes of bone graft plus TGF beta 1 in the treatment of intrabony defect at baseline and 6 months Control Interve

Sponsors

Dr Shagun Desai
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. The sites should exhibit radiographic evidence of intrabony defects more than 3mm deep. 2. The site should exhibit 2 or 3 walled defects. 3. Interproximal probing depth more than 5mm following phase I therapy 4. Age between 20 to 55years. 5. Systemically healthy patient.

Exclusion criteria

Exclusion criteria: 1. Subjects who have received periodontal flap / regenerative therapy within the past 1 year. 2. Pregnant and lactating patients 3. Current smokers and tobacco users. 4. Patients who demonstrate poor oral hygiene maintenance and non-compliance. 5. Teeth with Grade III mobility. 6. Patients with uncontrolled systemic condition who are contraindicated for surgery.

Design outcomes

Primary

MeasureTime frame
To assess the clinical and radiographic outcomes of bone graft plus TGF-beta1 in the treatment of intrabony defect. To assess the clinical and radiographic outcomes of bone graft alone in the treatment of intrabony defect. To compare the clinical and radiographic outcomes in both the groups. Timepoint: 6 months

Secondary

MeasureTime frame
To compare the clinical and radiographic outcomes in both the groups. Timepoint: 6 months

Countries

India

Contacts

Public ContactDr Priyadarshini Nadig

Manubhai Patel Dental College and Hospital and ORI

priya_darshinikud@rediffmail.com7567796090

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026