Evaluating the use of a natural gel and Platelet-Rich Fibrin to improve healing after tooth removal

Evaluation of effectiveness of chitosan based nanoparticles in combination with Titanium-Prepared Platelet-Rich Fibrin (T-PRF) for socket preservation - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089715

Enrollment

Registered

2025-06-27

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K062- Gingival and edentulous alveolar ridge lesions associated with trauma

Interventions

Intervention1: Titanium-Prepared Platelet -Rich Fibrin and Chitosan nanoparticles: Chitosan naopartilces with Titanium-Prepared Platelet -Rich Fibrin will be placed in the socket after atraumatic extr

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients. 2. Non-smoker, over 18 years of age till the age of 60. 3. The tooth that needs to be extracted. Root fractures, endodontic treatment failure, internal and external resorption, over-retained primary teeth, non-restorable carious lesions, and residual roots are only a few possible causes. 4. Presence of grossly decayed tooth/teeth or root piece without the presence of purulent exudate or cellulitis.

Exclusion criteria

Exclusion criteria: 1. Individuals with compromised systemic health conditions that could impede bone healing and regeneration, such as diabetes mellitus, osteoporosis, blood problems, and titanium allergy. 2. History of alcoholism, excessive smoking or drug abuse. 3. Untreated dental diseases. 4. Pregnant and lactating mothers.

Design outcomes

Primary

Measure	Time frame
Chitosan nanoparticles and T-PRF will preserve the ridge with quicker healing in extraction sites.Timepoint: Assessment will be done at baseline, 3 months,6 months	—

Secondary

Measure	Time frame
NILTimepoint: NA	—

Countries

India

Contacts

Public ContactDr Prasad Dhadse

Datta Meghe Institute of Higher Education and Research

drprasaddhadse@gmail.com09422282446

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026