Role of resveratrol in healing after third molar removal

Therapeutic impact of resveratrol on healing and inflammation following mandibular third molar extraction - a randomized controlled study - Therapeutic impact of resveratrol on healing and inflammation following mandibular third molar extraction - a randomized controlled study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089678

Enrollment

Registered

2025-06-27

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Role of Resveratrol in Accelerating Postoperative Recovery After Surgical Extraction of Impacted Mandibular Third Molars: A Randomized Clinical Trial COMPARATOR AGENT: COMPARATOR AGE

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion Criteria: 1.Patients aged between 18 and 40 years. 2.Indicated for surgical extraction of a single impacted mandibular third molar (mesioangular, horizontal, or vertical impaction). 3.Systemically healthy individuals (ASA I or II). 4.Patients willing to participate and able to provide written informed consent. 5.Patients with no history of allergy to Resveratrol or any components of the formulation used. 6.Patients available for follow-up and compliant with postoperative instructions.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1.Patients with systemic conditions that may affect healing (e.g., diabetes mellitus, immunocompromised states). 2.Current or recent use (within the past 2 weeks) of anti-inflammatory, antioxidant, or immunosuppressive medications. 3. History of hypersensitivity or allergy to Resveratrol or related compounds. 4. Pregnant or lactating women. 5. Active infection or pathology at the surgical site. 6.History of alcohol or substance abuse. 7.Patients with poor oral hygiene or active periodontal disease near the surgical sites 8.Smoking or tobacco use in any form. 9.Participation in another clinical trial within the last 30 days.

Design outcomes

Primary

Measure	Time frame
Pain reduction assessed by Visual Analog Scale (VAS) on postoperative Day 1, Day 3, and Day 7. Swelling measured by linear facial measurements on Day 1, Day 3, and Day 7. Trismus assessed by maximum interincisal mouth opening on Day 1, Day 3, and Day 7.Timepoint: 7 days	—

Secondary

Measure	Time frame
Secondary Outcomes: Quality of wound healing assessed clinically using a standard wound healing index on Day 7. Incidence of postoperative complications such as infection, dry socket, or delayed healing. Adverse effects or any hypersensitivity reactions related to Resveratrol.Timepoint: 6 to 12 months	—

Countries

India

Contacts

Public ContactDr Nitin Bhagat

Manav Rachna Dental College

nitinbhagat.sds@mrei.ac.in9953784571

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026