To study how a combination of two medicines lidocaine and ketamine can help control the rise in blood pressure and heart rate that usually happens during certain stressful moments in open-heart surgery, like inserting the breathing tube, making the first cut, and opening the chest.

To evaluate the effect of combination of lidocaine and ketamine infusion on attenuation of hemodynamic response to intubation,skin incision and sternotomy in open adult valvular heart surgeries.A double blinded randomized controlled study. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089638

Enrollment

Registered

2025-06-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I05-I09- Chronic rheumatic heart diseases Health Condition 2: I083- Combined rheumatic disorders of mitral, aortic and tricuspid valves Health Condition 3: I083- Combined rheumatic disorders of mitral, aortic and tricuspid valves

Interventions

Intervention1: Lignocaine 1.5 mg/kg and Ketamine 0.2 mg/kg: Lignocaine 1.5 mg/kg and Ketamine 0.2 mg/kg given bolus initially and continued infusion until 10 Minutes after sternotomy Control Intervent

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients aged between 18 to 75 years, scheduled for elective open valvular heart surgery Both male and female patients will be included Patients with left ventricular ejection fraction (LVEF) greater than 40%, assessed by echocardiography within 1 week prior to surgery Patients undergoing elective open valvular heart surgery via median sternotomy American Society of Anesthesiologists (ASA) physical status classification Grade II or III Patients who provide written informed consent

Exclusion criteria

Exclusion criteria: Patient refusal Allergy to the study drug History of opioid abuse History of any addiction Cognitive dysfunction Raised intracranial pressure

Design outcomes

Primary

Measure	Time frame
Changes in heart rate, blood pressure, during intubation, skin incision, and sternotomyTimepoint: At the time of intubation, 5 minutes after intubation, at the time of skin incision,sternotomy,5minutes after sternotomy	—

Secondary

Measure	Time frame
Total dose of Propofol and Fentanyl requiredTimepoint: Intubation, skin incision , and sternotomy	—

Countries

India

Contacts

Public ContactJitendra kalbande

AIIMS RAIPUR

drjitu222@gmail.com9096447683

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026