Effect of Injection Pentoxifylline on Liver Regrowth in the Liver Donor after Right Side Liver Removal for Liver Donor surgery for living donor Liver Transplant

Effect of Pentoxifylline on Liver Regeneration after Right Lobe Donor Hepatectomy A Randomized control Trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089632

Enrollment

Registered

2025-06-26

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z526- Liver donor

Interventions

Intervention1: Injection Pentoxifylline: Intravenous Pentoxifylline 1 mg/kg/hr dissolved in Plasma Lyte 12 hours before to 72 hours after Surgery Control Intervention1: Intravenous Fluid (PLasmalyte/

Eligibility

Inclusion criteria

Inclusion criteria: All Voluntary Healthy Liver Donors undergoing Right Lobe Donor Hepatectomy

Exclusion criteria

Exclusion criteria: Negative consent Hypersensitivity to pentoxifylline

Design outcomes

Primary

Measure	Time frame
To assess effect of Pentoxifylline supplementation on Anatomical (Volume) Regeneration of liver in the Perioperative period (POD-14) in Right lobe donor HepatectomyTimepoint: On Post-operative Day-14	—

Secondary

Measure	Time frame
To evaluate the effect of Pentoxifylline on Liver function Tests- Time to NormalizationTimepoint: Baseline, POD- 1 to 7 and POD 14;To evaluate the effect of Pentoxifylline on biomarkers of liver regeneration (HGF, TNF-alpha, IL-6, TGF Beta, AFP)Timepoint: Baseline, POD-3 and POD-7;To study the effect of Pentoxifylline supplementation on post-operative complications in donor right hepatectomyTimepoint: Discharge from hospital	—

Measure

Time frame

To evaluate the effect of Pentoxifylline on Liver function Tests- Time to NormalizationTimepoint: Baseline, POD- 1 to 7 and POD 14;To evaluate the effect of Pentoxifylline on biomarkers of liver regeneration (HGF, TNF-alpha, IL-6, TGF Beta, AFP)Timepoint: Baseline, POD-3 and POD-7;To study the effect of Pentoxifylline supplementation on post-operative complications in donor right hepatectomyTimepoint: Discharge from hospital

—

Countries

India

Contacts

Public ContactParneet

Institute of liver and Biliary Sciences, New Delhi

dr.nils.p@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026