Health Condition 1: E02- Subclinical iodine-deficiency hypothyroidism Health Condition 2: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention1: Levo thyroxine Tablet: Levothyroxine tablet will be given to Subclinical Hypothyroid patients to look for any effect on renal function
Intervention2: Intervention: oral Levothyroxine su
Sponsors
ARINDAM NASKAR
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 to 65 years Patients who give informed consent
Exclusion criteria
Exclusion criteria: Pregnant and lactating Type 1 DM heart failure (NYHA III AND IV) Atrial fibrillation Chronic liver disease ( child pugh C) Patients on levothyroxine therapy or anti-thyroid medications Patients on any medications that can affect thyroid hormone function eg amiodarone or lithium Diagnosed case of thyroid malignancies BMI greater than 40kg/m2 Thyroid surgeries
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the change in eGFR among diabetic patients with Subclincal Hypothyroidism following Levothyroxine therapyTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Proportion of patients with sustained decline in the estimated GFR of at least 50% 2) Proportion of patients developing End Stage Renal Disease (ESRD) Any changes in :- 3) Urine albumin-creatinine ratio 4) Lipid profile 5) AST, ALT 6) Uric acidTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactARINDAM NASKAR
School of Tropical Medicine
Outcome results
None listed