Health Condition 1: K70-K77- Diseases of liver
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Jamia Hamdard
Eligibility
Inclusion criteria
Inclusion criteria: Participants aged 18 to 65 years old Participants with a diagnosis of Metabolic dysfunction-associated fatty liver disease (MAFLD) confirmed by ultrasound and Fibroscan. Presence of at least one metabolic risk factor, such as type 2 diabetes mellitus (T2DM), obesity, or metabolic dysregulation. Willingness and ability to provide written informed consent. Healthy human volunteers for controls.
Exclusion criteria
Exclusion criteria: History of significant alcohol consumption exceeding established thresholds for men and women. Presence of coexisting chronic liver diseases or history of hepatotoxic drug use. Advanced systemic illnesses or malignancies. Patients having any other inflammatory diseases like arthritis, IBS Patients undergone any liver surgery or transplantation. Patients having history of head injury, neurocognitive disorder, or any other neuronal disease. Individuals with TB , any form of malignancies present or history of HIV-AIDS or any disease that could impair the biomarkers levels. Individuals currently taking medications that significantly impact glucose metabolism or biomarker levels (e.g.corticosteroids, certain antipsychotics). Individual with acute infection or inflammatory conditions at the time of recruitment. Pregnant individuals or those planning to become pregnant during study period will be excluded due to potential confounding effects on biomarkers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the correlation between serum levels of YKL-40 and IL-6 with liver fibrosis stages using the Novel Fibrosis Index (NFI) in MAFLD patients.Timepoint: Single Time Point | — |
Secondary
| Measure | Time frame |
|---|---|
| To validate the Novel Fibrosis Index (NFI) against Fibroscan & APRI To assess the relationship between IL-6 & YKL-40 levels in MAFLD patients To compare YKL-40 levels with age, gender, BMI, & diet in MAFLD patientsTimepoint: Single Time Point | — |
Countries
India
Contacts
Public ContactDr Mohd Ashif Khan
Jamia Hamdard
Outcome results
None listed