Health Condition 1: I710- Dissection of aorta
Conditions
Interventions
Intervention1: Cytosorb 300mL device: The CytoSorb Device (CytoSorb) is a non-pyrogenic, sterile, single-use device containing adsorbent polymer beads designed to
remove cytokines, as blood passes thr
Sponsors
Medanta The Medicity
Cytosorbents Europe GmbH
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient eligible for surgery on CPB for acute type A aortic dissection with expected CPB duration of at least 120 minutes. 2. Consent obtainable from patient/LAR
Exclusion criteria
Exclusion criteria: 1. Preoperative resuscitation OR 2. Withdrawal from active therapy OR 3. Expected to die within 24 hours OR 4. Pregnancy OR 5. Preoperative infection/sepsis 6. Patients on chemotherapy/ Immunosuppressants/systemic steroids 7. Refusal of Consent
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1.IL-6, PCT, lactate levels (at pre-defined time-points) 2. Cumulative volume and duration of vasoactive and inotropic medications up to 48 hours post-operatively. 3.Multi-organ dysfunction syndrome (MODS). 4.30 day mortality Timepoint: 12 months | — |
Primary
| Measure | Time frame |
|---|---|
| Peri-operative hemodynamic stability, as evidenced by the relative difference of the VIS score (at pre-defined time-points) until 48 hours postoperatively. 2.Length of stay in ICU and hospital Timepoint: 12 months | — |
Countries
India
Contacts
Public ContactDr Ajmer Singh
Institute of Critical care and Anesthesia
Outcome results
None listed