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Effect of Oral Zinc Supplementation in Neonatal Jaundice

Effect of Zinc Oral Supplementation in Hyperbilirubinemia (ZOSH) on Serum Bilirubin Levels in Neonates Requiring Phototherapy: A Double-blind Randomized Controlled Trial - ZOSH Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089511
Enrollment
104
Registered
2025-06-25
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P590- Neonatal jaundice associated withpreterm delivery Health Condition 2: P599- Neonatal jaundice, unspecified

Interventions

Intervention1: Oral Zinc (20mg/5ml): 1.25 ml Per oral in term neonates for 3 days and 0.25 ml per kg per oral for 3 days in pre term neonates Control Intervention1: D10: same volume as intervention

Sponsors

AIIMS Raipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All pre-term and term neonates admitted to NICU with hyperbilirubinemia for phototherapy

Exclusion criteria

Exclusion criteria: 1. Neonates with direct hyperbilirubinemia 2. Neonates with other systemic illnesses, severe sepsis, severe respiratory disease requiring mechanical ventilation, oral intolerance, and major gross congenital anomalies . 3. Neonates whose parents refuse to give consent. 4. neonates requiring exchange transfusion at admission for hyperbilirubinemia

Design outcomes

Primary

MeasureTime frame
Sequential levels of serum bilirubin during hospital stay at 24 hours and at time of dischargeTimepoint: 24 hours post start of phototherapy

Secondary

MeasureTime frame
1. Duration of phototherapy (in hours) 2. Duration of hospital stay 3. Any adverse effect of Zinc 4. Readmission with the same symptoms 5. cost of therapy Timepoint: 24 hours after start of phototherapy, at the time of discharge & adverse effects at any time during the course of stay.

Countries

India

Contacts

Public ContactChandra Prakash

AIIMS Raipur

triptyn@aiimsraipur.edu.in9826130218

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026