Health Condition 1: F321- Major depressive disorder, singleepisode, moderate
Conditions
Interventions
Intervention1: transcranial direct current stimulation: tDCS works by applying a low electrical current to specific brain areas, especially the dorsolateral prefrontal cortex (DLPFC), which plays a cr
Sponsors
Dr Roli Gupta
Eligibility
Inclusion criteria
Inclusion criteria: Male or Female patients in the age group of 18 to 65 years. Diagnosis of Major Depressive Disorder (MDD) according to ICD 11 criteria. Major Depressive Disorder, indicated by a baseline HAM D21 score (for example ,more than 8) Currently receiving SSRI treatment or about to initiate SSRI treatment. Ability to provide informed consent and comply with study procedure. Subjects with Unipolar Depression.
Exclusion criteria
Exclusion criteria: History of bipolar disorder, schizophrenia, or any psychotic disorders. Neurological conditions, such as epilepsy, history of seizures, or significant head injury. Presence of metallic implants or devices in the head that contraindicate tDCS. Pregnancy or breastfeeding women. Unstable or severe medical conditions that might interfere with participation or assessment. Subjects with pre existing cognitive impairment or mental retardation. Subjects with history of substance use (except nicotine and/or caffeine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in depression severity, assessed using the Hamilton Depression Rating Scale (HAM-D21) at baseline, week 3, and week 6. Timepoint: at baseline, 3 weeks and 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Feasibility & tolerability of tDCS as an add-on therapy. Response in the Indian population, contributing to personalized treatment approaches. Timepoint: at baseline, 3 weeks & 6 weeks | — |
Countries
India
Contacts
Public ContactDr Roli Gupta
Shri B.M Patil Medical college, hospital and research centra
Outcome results
None listed