Comparison of adding drugs to extend and improve the pain relief in spinal anesthesia

A Comparative study of the efficacy of various adjuvant drugs in spinal anesthesia Nalbuphine, Buprenorphine and clonidine with Bupivacaine in Elective Surgeries at a tertiary care hospital

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089448

Enrollment

160

Registered

2025-06-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group D Bupivacaine: Bupivacaine 15mg intrathecal single dose stat 5 minutes Control Intervention1: Group A Buprenorphine: Bupivacaine 15mg with Buprenorphine 150mcg Intrathecal single

Eligibility

Inclusion criteria

Inclusion criteria: Patients of ASA 1,2 and 3 undergoing Elective surgeries under Spinal anesthesia

Exclusion criteria

Exclusion criteria: - cardiac diseases : IHD, CAD - respiratory diseases : COPD, ILD, Asthma - neuropsychiatric disorders - Obese patients , Obstructive sleep apnea - Difficult airway and intubation - Children and pregnant patients

Design outcomes

Primary

Measure	Time frame
To compare the time of onset of the block- sensory and motor, the 2 segment regression time, the total duration of sensory block, hemodynamicsTimepoint: Baseline, then every 5 minutes till 3 hours.	—

Secondary

Measure	Time frame
Pain scores, Ramsay sedation scores, Onset of sedation of the three drugsTimepoint: Baseline, every 5 minutes during the surgery for 4 hours	—

Countries

India

Contacts

Public ContactDr Shirley Stephen

Rajiv Gandhi Institute of Medical Sciences Adilabad Telangana

shirl_jip@yahoo.co.in9488651342

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026