Treatment of Nail Psoriasis with Methotrexate 1% Gel Versus Tofacitinib 2% Ointment With Fractional CO2 Laser as a Drug Delivery System

A Randomized Controlled Trial Of Methotrexate 1% Gel Versus Tofacitinib 2% Ointment In The Treatment of Nail Psoriasis With Fractional CO2 Laser as a Drug Delivery System - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089420

Enrollment

Registered

2025-06-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L408- Other psoriasis

Interventions

Intervention1: Fractional co2 laser with Tofacitinib 2% ointment in nail psoriasis: Fractional co2 laser followed by topical application of tofacitinib 2% gel over the psoriatic nail Intervention2: A

Eligibility

Inclusion criteria

Inclusion criteria: Patients more than 18 years of age Patients not giving consent for the study Patients with previous topical, or systemic anti-psoriatic agents within 3 months prior to the study Pregnant and lactating females

Exclusion criteria

Exclusion criteria: Patients less than 18 years of age Patients not giving consent for the study Patients with previous topical, or systemic anti-psoriatic agents within 3 months prior to the study Pregnant and lactating females

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy of fractional co2 laser with methotrexate 1% gel and fractional co2 laser with tofacitinib 2% ointment in the treatment of nail psoriasis Timepoint: The nail changes improvement will be assessed at baseline,2 weeks, 4 weeks,6 weeks and 8 weeks Patients are followed up for 1 month	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Akshata yadav S

Sri Devaraj Urs Medical College

akshatayadav453@gmail.com09483145396

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026