Comparing Dexmedetomidine and Fentanyl for reducing Propofol use during laparoscopic abdominal surgery

A randomized comparative study of propofol consumption for achieving adequate bispectral index using intravenous dexmedetomidine versus fentanyl in patients undergoing laparoscopic abdominal surgery under general anesthesia at SMS medical college jaipur - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089404

Enrollment

100

Registered

2025-06-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Fentanyl: 2 mcg per kg intravenously Intervention2: Dexmedetomidine: 1 mcg per kg intravenously Control Intervention1: Dexmedetomidine: 1 mcg per kg intravenously Control Intervention2:

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective laparoscopic surgery under general anesthesia Patients consenting to participate Patients having ASA 1 and 2 Patients with mallampatti grade 1 and 2

Exclusion criteria

Exclusion criteria: Patient with anticipated difficult bag and mask ventilation Patient with known risk of aspiration Patient with uncompensated cardiovascular pulmonary neurological hepatorenal and endocrine disorders

Design outcomes

Primary

Measure	Time frame
Mean Propofol consumption using IV Dexmedetomidine to achieve BIS 50 Mean Propofol consumption using IV Fentanyl to achieve BIS 50 Mean time to achieve BIS 50 using IV Dexmedetomidine Mean time to achieve BIS 50 using IV Fentanyl Timepoint: At induction	—

Secondary

Measure	Time frame
Mean hemodynamic parameters SBP DBP MAP HR SPO2Timepoint: Baseline After induction Just after intubation 5 min 10 min 15 min 20 min 30 min 40 min 50 min	—

Countries

India

Contacts

Public ContactDr Harpreet kaur

Sawai man singh medical college

priy251019@gmail.com8871041948

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026