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Effect of simvastatin as root canal medicament in diabetic patients.

Comparative evaluation of effect of simvastatin and calcium hydroxide as intracanal medicaments in diabetic patients with periapical lesion using cone beam computed tomography - an observational study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089386
Enrollment
24
Registered
2025-06-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Simvastatin: Intracanal medicament for root canal treatment for 1 week and the lesion size reduction will be assessed at 1,3,6 and 9 months Control Intervention1: Calcium hydroxide: Int

Sponsors

SRM Dental College, Ramapuram
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Diabetic patients aged between 40 to 60 years Patients under ASA two category Single rooted teeth with single canal and closed apex Diabetic Patients diagnosed with pulp necrosis and symptomatic apical periodontitis with PAI score less than two

Exclusion criteria

Exclusion criteria: Patients in ASA one three four and five categories. Patients under any medication for a week Patients with periapical pathology with PAI score greater than 2 Patients with chronic apical periodontitis Patients with weeping canals Patients with mid-treatment flareups Teeth with cracks, vertical root fracture, internal & external resorption. Multirooted teeth, Single rooted teeth with multiple canals. Teeth with immature apex. Patients with calcified canals

Design outcomes

Primary

MeasureTime frame
To assess the post-operative healing following placement of calcium hydroxide as intracanal medicament in diabetic patients with periapical lesion using CBCT. To assess the postoperative healing following placement of simvastatin as intracanal medicament in diabetic patients with periapical lesion using CBCT. To compare & analyse the post-operative healing following the placement of simvastatin & calcium hydroxide as intracanal medicament in diabetic patients with periapical lesion using CBCT Timepoint: 18 months—

Secondary

MeasureTime frame
To compare & evaluate post-operative pain using Heft Parker VAS scale following the placement of simvastatin and calcium hydroxide as intracanal medicament in diabetic patients with periapical lesion.Timepoint: 7 days—

Countries

India

Contacts

Public ContactDr Kritika Selvakumar

SRM Dental College, Ramapuram

kavithasanjeev02@gmail.com9940048022

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026