Health Condition 1: E116- Type 2 diabetes mellitus with other specified complications
Conditions
Interventions
Intervention1: Injectmncxnc: hxiuhiuashuiq
Intervention2: Local injection of long acting insulin over diabetic foot ulcer: In Intervention group half the dose of calculated isophane insulin will be di
Sponsors
Dr Sandeep Singh
Eligibility
Inclusion criteria
Inclusion criteria: 1) Confirmed diagnosis of diabetes mellitus with HbA1c between 7-9% 2) Presence of a diabetic foot ulcer with duration exceeding three weeks 3) Patients willing to participate and provide informed consent 4) Patients able to comply with the study protocol and follow-up requirements
Exclusion criteria
Exclusion criteria: 1) Patients with extensive or complete necrosis requiring immediate amputation 2) Patients undergoing immunosuppressive therapy, radiotherapy, or treatment with corticosteroids or anticoagulants 3) Patients with peripheral vascular disease 4) Patients with any malignancy 5) Patients unable to comply with the study protocol or follow-up requirements 6) Patients who decline to participate or are unable to provide informed consent 7) Pregnant women and nursing mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Angiogenesis as measured by CD34 expression through immunohistochemical stainingTimepoint: Angiogenesis as measured by CD34 expression through immunohistochemical staining on day 0, day 5 and day 12 | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in wound surface area (measured in cm ) Timepoint: on day 0 and day 12;Wound contraction percentageTimepoint: On day 0 and day 12 | — |
Countries
India
Contacts
Public ContactDr Manabendra Baidya
Government Institute of Medical Sciences
Outcome results
None listed