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To see whether patients blood count and peripheral smear can diagnose severe infections and compare with other tests like procalcitonin.

Comparison of complete blood count and peripheral smear with procalcitonin and C reactive protein in diagnosis and prognostication of community acquired bacterial sepsis: A multicenter study in lower-middle income country - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089374
Enrollment
200
Registered
2025-06-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: A419- Sepsis, unspecified organism

Interventions

Intervention1: Complete blood count (CBC) and peripheral smear (PS) Complete Blood count will include Hemoglobin (Hb), Platelet count (PC), Total Leucocyte Count (TLC), Differential leucocyte count (D
and relevant ratios Peripheral smear analysis will be done for Band cells, Myelocytes (My), Metamyleocytes (MMy), Toxic granulations (TG), Cytoplasmic Vacuolisation (CV) and Dohle Bodies (D). Blood sa

Sponsors

Dr Ruchi Gupta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient presenting to ICU with community acquired bacterial sepis from ER or hospital stay less than 24hrs meeting more than or equal to 2 SIRS criteria will be evaluated for inclusion into bacterial sepsis (S-SIRS) or NI- SIRS group. 2.Unconfirmed etiologies of SIRS will be included in the study subject in case of positive culture reports.

Exclusion criteria

Exclusion criteria: 1.Hospitalization in last 3 months 2.Immediate post-operative status 3.Pregnancy 4.Immunosuppressants 5.Immunocompromised states like AIDS 6.Immune-deficiency disorders 7.Haematological malignancies 8.Patients with known or suspected non-bacterial causes of SIRS like fungal, viral, rickettsial, and parasitic infections.

Design outcomes

Secondary

MeasureTime frame
To analyze the combination of components of CBC-PS differentiating bacterial sepTo calculate the correlation coefficient of components of CBC-PS with APACHE II and compare it with PCT and CRP in patients of bacterial sepsis from NI-SIRS. Timepoint: Within 2 hours of admission;To compare CBC-PS with Procalcitonin and CRP on day 1 and day 4 of admission in predicting 30-day mortality in patients of bacterial sepsis.Timepoint: 30 day of admission;To evaluate correlation of CBC-PS with severity (APACHE And SOFA) of illness and compare it with PCT and CRP in patients of bacterial sepsisTimepoint: Admission (Day1) and on day 4—

Primary

MeasureTime frame
To compare to diagnostic accuracy of components of CBC-PS (Hb, PC, TLC, DLC, Bn, My, MMy, TG, and D; and relevant ratios) with PCT and CRP in bacterial sepsis and non-infective SIRS.Timepoint: Within 2 hours of admission—

Countries

India

Contacts

Public ContactDr Sumit Ray

Holy Family Hopsital

ruchi_gupta.mamc@yahoo.co.in9910695602

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026