Skip to content

Comparing the Effects of Probiotic, Chlorhexidine, and Fluoride Mouthwashes on Plaque and Gum Health: A Randomized Clinical Study

Comparative evaluation of anti-plaque and anti-gingivitis effect of probiotic, chlorhexidine, and fluoride mouthwashes. A triple-arm parallel randomized controlled trial. - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089371
Enrollment
45
Registered
2025-06-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K051- Chronic gingivitis

Interventions

Intervention1: Darolac Z probiotic: Darolac-Z is a probiotic formulation that contains beneficial strains such as Lactobacillus rhamnosus, Bifidobacterium, along with zinc, and is commonly used to pro

Sponsors

Santosh Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: -Systemically healthy subjects in the age group of 18-40 years. -No Periodontal therapy within the preceding 3 months -Patient with mild-moderate gingivitis

Exclusion criteria

Exclusion criteria: Age below 18 years. Subjects with a history of oral prophylaxis within the past six months. Subjects on any antibiotic therapy in the past three months Patients with any systemic disease and pregnant patients.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the changes in clinical parameters specifically the Plaque Index and Gingival Index within and between the three groups (probiotic, chlorhexidine, and fluoride mouthwashes)Timepoint: 2 weeks

Secondary

MeasureTime frame
To observe and compare patient compliance with the use of each mouthwash over the 2-week study period. To identify and record any side effects or adverse reactions associated with the use of probiotic, chlorhexidine, or fluoride mouthwashes during the intervention.Timepoint: 2 weeks

Countries

India

Contacts

Public Contactsaim abbasi

Santosh Demeed to be University

drshivani.sharma@santosh.ac.in9971794472

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026