Health Condition 1: G053- Encephalitis and encephalomyelitisin diseases classified elsewhere
Conditions
Interventions
Intervention1: Probiotic therapy: Probiotic includes S. thermophilus, L.acidophilus, L. plantarum, L. paracasei, L. Helveticus, L. brevis, B. lactis ( 2 strains
)
Weight based:
5 - 10 KG - 10 - 20 Bil
Sponsors
Special research grant for MDDM students of Department of Pediatrics and microbiology
Eligibility
Inclusion criteria
Inclusion criteria: All premorbidly well children between age group of more than 28 days to less than 13 years admitted in PICU with non traumatic coma of any etiology requiring mechanical ventilation.
Exclusion criteria
Exclusion criteria: Known chronic illness, Immunodeficiency states, Malignancy, Prior steroids or immunotherapy, severe acute malnutrition, Probiotic therapy in last 1 month , Not able to start enteral nutrition for more than 48 hours of PICU admission, Prior antibiotics more than 48 hrs and parents who refused consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Profile of gut microbiome in both groupsTimepoint: At baseline and 7 days of probiotic and placebo therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Profile of cytokines in probiotics & placebo groupTimepoint: Baseline, day 3 & day 7 of enrollment;Oxygenation indices among both groupsTimepoint: Baseline & day 7;Ventilation free daysTimepoint: day 28;Health care associated infections & antibiotic usageTimepoint: at discharge;28 day mortalityTimepoint: Day 28;GOSE scale among both groupsTimepoint: at discharge & 3 months;POPC, PCPC, HUI 2Timepoint: at 3 months | — |
Countries
India
Contacts
Public ContactArun Bansal
Post Graduate Institute Of Medical Education and Research
Outcome results
None listed