Comparing nasal spray and injection forms of nitroglycerine to control blood pressure changes during laparoscopic surgery.

Comparison of effectiveness of intranasal Nitroglycerine spray versus intravenous bolus Nitroglycerine for attenuation of hemodynamic Response to pneumoperitoneum in laparoscopic Surgery- a double blinded randomized clinical comparative trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089369

Enrollment

Registered

2025-06-23

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: Nitroglycerine Spray: patients will receive intranasal nitroglycerine 400 mcg spray once 2 mins prior to pneumoperitoneum. Blood pressure, peripheral capillary oxygen saturation and hea

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adults aged between 18-65 years 2.Patients posted for elective laparoscopic 3.American society of anaesthesiologists (ASA) physical status I or II 4.Body Mass Index 18.5-30 kg/m2 5.Non pregnant, Non lactating females 6.Patients who provided written informed consent

Exclusion criteria

Exclusion criteria: Hypersensitivity to nitroglycerine Severe Anaemia History of significant cardiovascular disorders -ischemic heart disease, uncontrolled hypertension, arrhythmias, heart failure Patients on medications which interact with nitroglycerine - sildenafil, nitrates Unable or unwilling to comply with study protocol Patients with ASA greater than 2

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of intranasal nitroglycerine spray versus intravenous nitroglycerine in attenuating the hemodynamic response (changes in blood pressure and heart rate) to pneumoperitoneum during laparoscopic surgery.Timepoint: Blood pressure, peripheral capillary oxygen saturation and heart rate measured at 2 mins before and 2, 4, 6, 8, 10, 15, 30, 45 minutes, and 1 hour after pneumoperitoneum initiation.	—

Measure

Time frame

To compare the efficacy of intranasal nitroglycerine spray versus intravenous nitroglycerine in attenuating the hemodynamic response (changes in blood pressure and heart rate) to pneumoperitoneum during laparoscopic surgery.Timepoint: Blood pressure, peripheral capillary oxygen saturation and heart rate measured at 2 mins before and 2, 4, 6, 8, 10, 15, 30, 45 minutes, and 1 hour after pneumoperitoneum initiation.

—

Secondary

Measure	Time frame
To see for adverse effects associated with intranasal nitroglycerine & intravenous nitroglycerineTimepoint: Blood pressure, peripheral capillary oxygen saturation & heart rate measured at 2 mins before & 2, 4, 6, 8, 10, 15, 30, 45 minutes, & 1 hour after pneumoperitoneum initiation.	—

Countries

India

Contacts

Public ContactSushree Das

IMS and SUM Hospital

das.sushri@gmail.com9132425105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026