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To compare effect of a medicine on pain reduction before starting of root canal treatment

Effect of premedication with ibuprofen on pain perception in patients during root canal procedure with symptomatic irreversible pulpitis with apical periodontitis - A randomised clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089343
Enrollment
60
Registered
2025-06-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Ibuprofen: Ibuprofen Dose- 400mg Frequency- 1 time route of administration- Oral Duration- 30 minutes before procedure Control Intervention1: Placebo: placebo Dose- 400mg Frequency

Sponsors

Dr Amreen Fidose
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients requiring non-surgical endodontic therapy with symptomatic irreversible pulpitis with apical periodontitis

Exclusion criteria

Exclusion criteria: Patients who have taken analgesic or anti-inflammatory drugs within 24 hours of initiation of root canal treatment. subjects with known allergy to NSAIDS, pregnant women, immunocompromised patients, occlusal disorders,periodontitis, systemic disorders like asthma , GI disorders, renal and hepatic diseases.

Design outcomes

Primary

MeasureTime frame
To assess pain perception with premedication of Ibuprofen in patients during root canal procedure with symptomatic irreversible pulpitis with apical periodontitis. Timepoint: 15 minutes , 30 minutes—

Secondary

MeasureTime frame
To assess pain perception with premedication of Placebo in patients during root canal procedure with symptomatic irreversible pulpitis with apical periodontitis. To compare the pain perception with premedication of Ibuprofen and Placebo in patients during root canal procedure with symptomatic irreversible pulpitis with apical periodontitis. Timepoint: 15 minutes, 30 minutes;To compare gender distribution for pain perception.Timepoint: 15 minutes , 30 minutes—

Countries

India

Contacts

Public ContactAmreen Firdose

Dayananda Sagar Dental college

aaamovies1000@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026