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Comparing dexmedetomidine and butorphanol for reducing muscle jerks during anaesthesia with etomidate in surgical patients.

Effect of dexmedetomidine and butorphanol pretreatment on myoclonus during induction of anaesthesia with etomidate - Randomised controlled study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/089341
Enrollment
159
Registered
2025-06-23
Start date
Unknown
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Pretreatment of 0.5mcg/kg dexmedetomidine or 0.015mg/kg of butorphanol: Study participants will be randomised into three groups with intervention group receiving either pretreatment of

Sponsors

Parvathy C B
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients in the age group 18 to 60 years Patients of American Society of Anaesthesiologists Physical Status grade I or II

Exclusion criteria

Exclusion criteria: 1. Patients with history of allergy to study drugs (etomidate, dexmedetomidine, butorphanol) 2. Patients with history of diabetes, hypertension, cardiovascular, respiratory or neurologic disease, psychiatric disorders, impaired renal and hepatic function. 3. Patients with adrenocortical dysfunction 4. Patients with morbid obesity 5. Patients who received sedatives, analgesics or opioids within the previous 24 hours 6. Patients with hiatal hernia and symptomatic gastroesophageal reflex. 7. Patients having problems in communication 8. Patients who are pregnant or lactating. 9. Patients with anticipated difficult airway or difficult venous access or disorders of lipid metabolism

Design outcomes

Primary

MeasureTime frame
Severity of myoclonus after induction with EtomidateTimepoint: Severity of myoclonus after induction with Etomidate within 60sec

Secondary

MeasureTime frame
nilTimepoint:

Countries

India

Contacts

Public ContactRUPENDRA SINGH THOKCHOM

Regional Institute of Medical Sciences, Imphal

penbeeru63@gmail.com9774247043

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026