Health Condition 1: D630- Anemia in neoplastic disease
Conditions
Interventions
Intervention1: umbilical cord blood transfusion: umbilical cord blood transfusion in patients with radiotherapy with or without chemotherapy induced bone marrow suppression
Control Intervention1: not
Sponsors
IPGMER and SSKM Hospital, Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: Performance status less than or equal to 2 More than 18 years of age. Persistent Grade 2 or higher hematological toxicities after chemotherapy or radiotherapy For at least 2 weeks. Toxicities will be assessed by EORTC CTCAE criteria and RTOG Radiation Toxicity Grading. Haemoglobin less than 10 gm/dl. / Total leucocyte count less than 3000/cumm. / Absolute neutrophil count less than 1500/cumm. / Platelet count less than 75000/cumm. Patients who will give consent to be included in the cord blood transfusion study.
Exclusion criteria
Exclusion criteria: Patients who have developed Hemotological toxicities due to causes other than radiation therapy and chemotherapy. Patients who have received growth factors, such as G-CSF, GM-CSF, erythropoietin, thrombopoetin within one weeks. Patients with distant metastasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| If study shows that cord blood transfusion is quite effective in amelioration of anti-malignant therapy induced myelosuppression in Patients in our country, then this treatment can also be applied in anti-malignant therapy induced bone marrow suppression and also in other diseases causing bone marrow suppression.Timepoint: The complete blood count (CBC) of the patient will be assesed at baseline, 1 week and 2 weeks post transfusion | — |
Secondary
| Measure | Time frame |
|---|---|
| nilTimepoint: nil | — |
Countries
India
Contacts
Public ContactDr Priyanka Das
IPGMER and SSKM Hospital Kolkata
Outcome results
None listed