The study evaluates the effectiveness of Pregabalin versus Duloxetine in managing acute post-operative pain in patients undergoing spinal anesthesia

Evaluation of preemptive analgesic effect of duloxetine and pregabalin in patients undergoing surgeries following sub arachnoid block :A randomized controlled double blinded study - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089308

Enrollment

Registered

2025-06-23

Start date

Unknown

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Tab Duloxetine 60 mg 2hrs prior to surgery in preoperative room: to compare the time taken for the first rescue analgesia in duloxetine and pregablin group Control Intervention1: Tab Pr

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 years to 60years ASA -1,2 Elective total abdominal surgeries and lower limb surgeries

Exclusion criteria

Exclusion criteria: age less than 18 years and more than 60 years,fever, drug sensitivity, drug abuse, pregnant patients, renal hepatic cardiac diseases, uncontrolled blood pressure, patient refusing spinal anesthesia

Design outcomes

Primary

Measure	Time frame
To compare the time taken for first rescue analgesia in duloxetine and pregablin group Timepoint: 120mins	—

Secondary

Measure	Time frame
To assess Pre operative anxiety score using APAIS Questionnare and intraoperative sedation score using Numeric sedation score (NSS) To assess other hemodynamic changes , adverse effects of these drugs over 120 mins Timepoint: 120mins	—

Countries

India

Contacts

Public ContactDr ARUN KUMAR

Chettinad Hospital and research Institute

pugalenthi08@yahoo.co.in9489404818

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026