Comparing healing results when using or not using platelet-rich fibrin (PRF) in skin grafting after oral cancer surgery

Comparison of outcomes of skin grafting with or without platelet rich fibrin (PRF) when used to cover the free flap donor site in a patient undergoing reconstruction for oral squamous cell carcinoma. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089263

Enrollment

Registered

2025-06-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C069- Malignant neoplasm of mouth, unspecified

Interventions

Intervention1: Platelet rich fibrin: Skin grafting with platelet rich fibrin applied to the free flap donor site in patients undergoing reconstruction for oral squamous cell carcinoma. PRF is used to

Eligibility

Inclusion criteria

Inclusion criteria: 1.Biopsy proven case of Oral squamous cell carcinoma. 2.All patients who have shown positive test on Allen test, as a pre-requisite to Radial Forearm Free Flap with or without PRF. 3.Patients undergoing free flap donor site closure requiring skin grafts. 4.Patients able to provide informed consent. 5.ASA I and II

Exclusion criteria

Exclusion criteria: 1.Any carcinoma other than Oral squamous cell carcinoma. 2.Patient who have undergone Recurrence or chemotherapy. 3.Patient who has undergone radiotherapy. 4.Patient who are lost to follow up. 5.ASA III and IV. 6.All patient not willing for Microvascular surgery.

Design outcomes

Primary

Measure	Time frame
Application of Platelet Rich Fibrin (PRF) to free flap donor sites will significantly enhance skin graft healing compared to conventional methods aloneTimepoint: Assessment will be done at 5,10,20,30,45,60,90 days	—

Secondary

Measure	Time frame
NILTimepoint: NA	—

Countries

India

Contacts

Public ContactDr Nitin Bhola

Datta Meghe Institute of Higher Education and Research

drnitinbhola@gmail.com9970070607

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026