Health Condition 1: G409- Epilepsy, unspecified
Conditions
Interventions
Intervention1: Low glycemic index treatment (LGIT): LGIT is a variant of the ketogenic diet with increased palatability and flexibility, featuring a fat-to-carbohydrate and protein ratio of approximat
Sponsors
Prof. (Dr.) Manjari Tripathi
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Patients aged between 18 to 55 years with a confirmed clinical diagnosis of Drug Resistant Epilepsy (DRE) and receiving treatment in the Neurology OPD of AIIMS New Delhi, having a seizure frequency of more than 2 per month for at least 6 months, and willing to begin with Low Glycemic Index Therapy (LGIT).
Exclusion criteria
Exclusion criteria: Exclusion Criteria: Patients not willing to participate, those with learning difficulties or vision/hearing impairments, inability to read English or Hindi script, pregnant and lactating mothers, presence of metabolic syndrome, surgically remediable cause for DRE, clinical features suggestive of in-born errors of metabolism, suspicion of metabolic disorder or systemic diseases including diabetes mellitus, cardiovascular disease, or metabolic disorders such as carnitine disease or beta oxidation defects, history of prior myocardial infarction, refusal to give consent, or those who have tried LGIT or similar dietary interventions in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with more than 50% seizure frequency reduction at 3 months after initiation of diet therapy.Timepoint: Baseline and at 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| o Rate and characteristics of short term (3 months) adverse events in LGIT. o Rate of withdrawal from the LGIT diet during the study period and reasons for withdrawal. o To assess change in parameters of Quality of life and behavior at 3 months in both the groups using semi-structured self-designed questionnaire.Timepoint: Baseline and at 3 months | — |
Countries
India
Contacts
Public ContactProf Dr Manjari Tripathi
Department of Neurology, All India Institute of Medical Sciences, New Delhi
Outcome results
None listed