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Understanding the role of altered mitochondrial function in Type 2 Diabetes Mellitus

Elucidating the role of altered mitochondrial function and inflammatory signaling in insulin resistance to Type 2 Diabetes Mellitus

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/089163
Enrollment
69
Registered
2025-06-19
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications Health Condition 2: E168- Other specified disorders of pancreatic internal secretion

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Intramural Fund from Manipal Academy of Higher Education (MAHE)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Men between 40 to 45yrs of age. 2. No history of diabetes mellitus (HbA1C less than or equal to 5.7%) 3.No major co-morbidity 4. Individuals with no history of tobacco/nicotine usage for past 3 months from the point of recruitment for the study. 5. Individuals with no history of consumption of alternative medicines for 3 months from the point of recruitment (Ayurverda, Homeopathy, Siddha, Naturopathy, Unani etc.) 6. Individuals screened and cleared for the following parameters: fasting and post prandial glucose, fasting insulin, CRP, Lipid profile, Plasma lactate, HbA1C. 7. Individuals with no evidence of any active infection or chronic disease.

Exclusion criteria

Exclusion criteria: 1.Individuals under 40yrs and above 45yrs of age. 2.Individuals with the history of comorbidity. 3.Individuals with history of smoking / nicotine usage / consumption of alternative medicine/ dietary changes as per alternative medicine. 4.Women recruits are excluded from the study. 5.Individuals who have undergone any surgical procedures within the past three months prior to recruitment will be excluded from participation in the study. 6.Individuals who are obese-BMI more than 30.

Design outcomes

Primary

MeasureTime frame
Altered biochemical parameters can be expected in T2DM patients.Timepoint: Baseline i.e. 0th time point—

Secondary

MeasureTime frame
Understanding the relationship between mitochondrial dysfunction & innate immune responses to IR in T2DM patients.Timepoint: Baseline i.e. 0th time point—

Countries

India

Contacts

Public ContactDr Ranita Ghosh Dastidar

Kasturba Medical College, Manipal, MAHE

ranita.gd@manipal.edu8088652524

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026