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A study to understand the problems and best methods related to removal of breathing tube inserted in windpipe of patients in operation theatres and intensive care unit

EXtubation related complications- an international observational study To Understand the impact and BEst practices in the operating room and intensive care unit (EXTUBE Study) - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/089091
Enrollment
3000
Registered
2025-06-18
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Control Intervention1: NIL: NIL

Sponsors

Toronto General hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All adult patients (greater than or equals to 18 years old) undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU during the specified enrollment window will be included.

Exclusion criteria

Exclusion criteria: Patients will be excluded if the extubation is: (i) performed in the context of withdrawal of life support measures or (ii) performed for tracheostomy decannulation. For each patient who is not included, reasons for exclusion will be reported.

Design outcomes

Primary

MeasureTime frame
The primary outcome will be the occurrence of at least one of the following (composite outcome) occurring within 60 minutes after the end of extubation 1. Severe hypoxemia (oxygen saturation as measured by pulse oximetry falls below SpO2 less than 80% for more than 5 minutes) 2. Cardiac arrest 3. Need for airway management (reintubation, insertion of a supraglottic airway, bag-mask ventilation).Timepoint: within 60 minutes of extubation—

Secondary

MeasureTime frame
Secondary outcomes will include the new occurrence of the following complications: 1. Difficult and complications related to airway management (eg esophageal intubation) if reintubation is required 2. Planned and unplanned non-invasive respiratory support or high flow nasal cannula 3. Emergency front of neck airway 4. Cardiac arrhythmia requiring chemical or electrical treatment 5.Severe hypotension 6. Severe hypertension 7. Aspiration of gastric contents 8. Pneumothorax/pneumo-mediastinum, 9. Dental injury 10. Airways injury Timepoint: within 60 minutes of extubation—

Countries

Australia, Canada, Germany, India, United Kingdom, United States of America

Contacts

Public ContactDr Sheila Nainan Myatra

Tata Memorial Hospital

sheila150@hotmail.com9820156070

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026