A study to understand the effects of using nasal tissue to help nasal wound to heal in patients who undergo surgery for brain tumor through the nose

Role of autologous free nasal mucosal graft on nasoseptal flap donor site healing in expanded endonasal endoscopic skull base surgeries - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/089007

Enrollment

Registered

2025-06-17

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: D352- Benign neoplasm of pituitary gland Health Condition 3: D353- Benign neoplasm of craniopharyngeal duct

Interventions

Intervention1: Autologous free nasal mucosal graft: Contralateral nasal septal mucosa as graft cover over the denuded nasoseptal flap donor site during surgery (once) Control Intervention1: No interve

Eligibility

Inclusion criteria

Inclusion criteria: Skull base tumor excision in which unilateral nasoseptal flap is harvested and used for reconstruction of the skull base

Exclusion criteria

Exclusion criteria: 1. Post radiotherapy 2. Revision pituitary cases 3. Tubercullum sella tumors 4. Malignancies involving nasal septum 5. Patient not giving consent

Design outcomes

Primary

Measure	Time frame
To assess if use of nasal septal mucosa as a graft can help in mucosalisation of nasoseptal flap donor site by fastening healing, reducing nasal obstruction and crusting and this will be compared to no interventionTimepoint: 2 weeks 6 weeks 3 months	—

Secondary

Measure	Time frame
1. To compare the healing time of nasal mucosal graft vs reverse nasoseptal flap & middle turbinate graft from existing literature 2. How many patients had complications like- graft necrosis, granulation tissue, infection Timepoint: 2 weeks 6 weeks 3 months	—

Countries

India

Contacts

Public ContactReshma Raj

Christian Medical College

reganupthomas@cmcvellore.ac.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026