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A study to assess the changes in levels of biomarkers of bone remodelling during tooth movement in patients undergoing fixed orthodontic treatment

Comparative evaluation of Apolipoprotein E, Interleukin-17 and PINP as a biomarker in Orthodontic tooth movement - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/06/088955
Enrollment
15
Registered
2025-06-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: Anterior retraction during Fixed Orthodontic treatment: En masse anterior teeth retraction during Fixed orthodontic treatment with MBT technique, Roth technique and Other Straight wire

Sponsors

Faculty of Dental sciences, Banaras Hindu University
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Class I Bimaxillary Protrusion and Class II malocclusion who require First premolar extraction. Patients with age between 14 years and 25 years Patients with moderate to good oral hygiene

Exclusion criteria

Exclusion criteria: Patients with poor oral hygiene and deep carious lesions Patients with one or more missing teeth Patients with Systemic Diseases, particularly bone disorders like Primary Hyperparathyroidism, Thyrotoxicosis or Hypothyroidism, Acromegaly or Hypopituitarism, hypogonadism, Vitamin D deficiency, Rheumatoid Arthritis, Multiple Myeloma and Liver diseases. Syndromic Patients Patients with Hyperlipidaemia and Hypercholesterolemia Patients under medications such as anti-osteoporotic, Vitamin D and Calcium, Thiazolidinediones, Thiazide Diuretics, etc.

Design outcomes

Primary

MeasureTime frame
Rate of Orthodontic tooth movementTimepoint: Baseline, 25 days of retraction and at 45 days of retraction

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactJebin Gladston D

Faculty of Dental Sciences, Banaras Hindu University.

drajitparihar@gmail.com8004925688

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026