This study compares the effects of normal dose of antibiotics versus reduced doses of antibiotics on kidney health and recovery in patients with sudden kidney damage and severe infection and very low blood pressure, known as septic shock.

Difference of effect between standard dose and renally adjusted dose of antibiotics on renal function and clinical cure among the patients having acute kidney injury with septic shock: A comparative randomised control study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088950

Enrollment

140

Registered

2025-06-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N179- Acute kidney failure, unspecified

Interventions

Intervention1: Dose adjustment of intravenous Antibiotics: Dose and frequency adjustment according to creatinine clearance of Intravenous Antibiotics in acute kidney injury patients with septic shock

Eligibility

Inclusion criteria

Inclusion criteria: Patients with AKI (as per KDIGO classification) Patients with septic shock

Exclusion criteria

Exclusion criteria: Age less than 18 years & above 65 years Patients with chronic kidney disease & on hemodialysis patients on nephrotoxic drugs

Design outcomes

Primary

Measure	Time frame
Compare renal function test & clinical outcome between standard dose & renal adjusted dose of antibiotics in patients of AKI with septic shockTimepoint: 15 days	—

Secondary

Measure	Time frame
compare clinical cure between standard dose & renal adjusted dose of antibiotics in patients of AKI with septic shockTimepoint: 15 days	—

Countries

India

Contacts

Public ContactDr Arun Raj Pandey

Institute of medical sciences, BHU

drarunrajpandey@gmail.com7704094669

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026