Prospective study to compare the post operative side effects of sugammadex and neostigmine as an agent of reversal for neuromuscular blockade in off pump coronary artery bypass grafting surgeries

A Prospective Randomized Study to Compare the Post operative side effects of sugammadex vs neostigmine for reversal of vecuronium-induced neuromuscular blockade in patients undergoing CORONARY ARTERY BYPASS GRAFTING off pump - NIL

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088927

Enrollment

112

Registered

2025-06-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I229- Subsequent ST elevation (STEMI) myocardial infarction of unspecified site

Interventions

Intervention1: To watch for time duration of reversal from neuromuscular blockade and to compare the post operative complications: When compared to neostigmine, sugammadex requires lesser time of onse

Eligibility

Inclusion criteria

Inclusion criteria: 1. 18 years of age or older 2. Scheduled for elective cardiac surgery with general anesthesia, invasive mechanical ventilation, complete median sternotomy

Exclusion criteria

Exclusion criteria: 1. Age less than 18 years 2. Patient scheduled for emergency or redo surgeries 3. Patients with history of COPD / Pulmonary hypertension / hepatic or renal dysfunction

Design outcomes

Primary

Measure	Time frame
Time from reversal administration at least 3 TOFR equal to or more than 0.9Timepoint: 3 minutes / 5 minutes / 10 minutes / 20 minutes / 30 minutes / 1 hour / 2 hour	—

Secondary

Measure	Time frame
Time of extubation from discontinuation of inhaled anaesthetic, Need for reintubation, Need for non invasive ventilation, Duration of oxygen requirement post surgery, Duration of ICU stay, Bradycardia, Bronchospasm, Cardiac arrest.Timepoint: At Baseline	—

Countries

India

Contacts

Public ContactDr Ranjith B Karthekeyan

Sri Ramachandra Institute of Higher Education and Research

ranjithkarthekeyan@sriramachandra.edu.in9841136568

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026