Study to see if pregabalin can reduce muscle twitching,pain,high potassium caused by a common anaesthesia drug during abdominal surgery.

Effect of Pregabalin on succinylcholine induced fasciculation, myalgia, hyperkalaemia in elective abdominal surgeries under general anaesthesia: A randomised double blind controlled study - nil

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088867

Enrollment

Registered

2025-06-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere

Interventions

Intervention1: pregabalin: Pregabalin 100mg orally will be given to half of the total sample size of the patients 60mins before abdominal surgery over 1min. Control Intervention1: 100mg glucose: for c

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients aged 18 60 years, ASA physical status I II, scheduled for elective abdominal surgery under general anaesthesia. 2)Patients requiring succinylcholine for intubation.

Exclusion criteria

Exclusion criteria: 1)Known allergyy to pregabalin or succinylcholine, 2)Conditions predisposing to hyperkalemia, 3)emergency surgeries 4)ASA three or four 5) pregnant or breastfeeding women

Design outcomes

Primary

Measure	Time frame
To compare the incidence and severity of succinylcholine-induced fasciculations by means of four-point scale between patients receiving pregabalin and those receiving placeboTimepoint: Assessed immediately within one minute after succinylcholine administration	—

Secondary

Measure	Time frame
postoperative myalgia. To compare the changes in serum potassium levels before and after succinylcholine administration in both groups. c. To assess postoperative pain by means of visual analogue scale(VAS) and analgesic requirements in first 24hrs as additional outcomes influenced by pregabalin. Time to first analgesic demand. Compare perioperative hemodynamic monitoring of blood pressure, heart rate, oxygen saturation. Ramsay score. Timepoint: myalgia after 24hrs post surgery, potassium levels after 5mins of intubation,postop pain at 0,4,8,12,16,20,24 hours, postop sedation 1st 6 hours, 8th, 12th,18th, and 24th hour.,postop hemodynamic parameters the 1st 6 hours, 8th, 12th,18th, and 24th hour	—

Measure

Time frame

postoperative myalgia. To compare the changes in serum potassium levels before and after succinylcholine administration in both groups. c. To assess postoperative pain by means of visual analogue scale(VAS) and analgesic requirements in first 24hrs as additional outcomes influenced by pregabalin. Time to first analgesic demand. Compare perioperative hemodynamic monitoring of blood pressure, heart rate, oxygen saturation. Ramsay score. Timepoint: myalgia after 24hrs post surgery, potassium levels after 5mins of intubation,postop pain at 0,4,8,12,16,20,24 hours, postop sedation 1st 6 hours, 8th, 12th,18th, and 24th hour.,postop hemodynamic parameters the 1st 6 hours, 8th, 12th,18th, and 24th hour

—

Countries

India

Contacts

Public ContactDR harshit kumar

DR SN Medical College

chandakhatri90@gmail.com8619236716

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026