Evaluation of level of biomarker IL-40 in various treatment modalities in treating gum problems subjects.

Evaluation of the levels of interleukin-40 in gingival crevicular fluid by open flap surgery in comparison with open flap surgery with i-prf and pocket sterilization procedure using diode laser in periodontitis subjects: a randomized controlled study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088862

Enrollment

Registered

2025-06-13

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Open flap debridement surgery with I-PRF: Extra-oral antisepsis will be performed with 5% povidone iodine solution and intra-orally 0.2% chlorhexidine digluconate will be given to rinse

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical status1. Periodontitis stage II, III. Probing pocket depth more than or equal to 4 mm after scaling and root planing.

Exclusion criteria

Exclusion criteria: Use of antibiotics or steroids during the last 3 months. Smoking habit. Diabetes mellitus. Pregnancy and lactating women. History of periodontal surgery or prosthetic restorations at the experimental teeth. Previous or current radiation therapy.

Design outcomes

Primary

Measure	Time frame
To measure the level of Interleukin 40Timepoint: at baseline and 3 month follow up	—

Secondary

Measure	Time frame
To assess the changes in Probing Pocket Depth, Relative Attachment Levels, full mouth plaque score and Gingival IndexTimepoint: At baseline and 3 months	—

Countries

India

Contacts

Public ContactDr Tejas Bobade

Government Dental college and Research institute

Drpurnimabhandari321@gmail.com8105254678

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026