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Evaluation of MTHFR gene methylation status in recurrent pregnancy loss

Association of methylation status of Methylenetetrahydrofolate Reductase (MTHFR) promoter region and Long Interspersed Nuclear Elements- 1 (LINE- 1) with recurrent pregnancy loss - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/088856
Enrollment
60
Registered
2025-06-13
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N96- Recurrent pregnancy loss

Interventions

Intervention1: Nil: Nil Intervention2: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Dr Anubhuti
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Females of or more 18 years of age who have passed through at least two consecutive pregnancy losses with the same spouse Age matched healthy fertile females who had full-term pregnancy and gave birth to at least one healthy child

Exclusion criteria

Exclusion criteria: Known cases of uterine malformations

Design outcomes

Primary

MeasureTime frame
The percentage of MTHFR promoter methylation and LINE- 1 methylation in RPLTimepoint: 4 weeks sample collection and processing 1 week data compilation 1 week statistical analysis—

Secondary

MeasureTime frame
1. MTHFR gene polymorphism in RPL 2. Serum/Plasma levels of homocysteine and serum levels of vitamin B12 and folate in RPL Timepoint: 4 weeks sample collection and processing 1 week data compilation 1 week statistical analysis—

Countries

India

Contacts

Public ContactDr Aman Jain

Maulana Azad Medical College

shanu.amanjain@gmail.com9529235175

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026