Health Condition 1: C250- Malignant neoplasm of head of pancreas
Conditions
Interventions
Intervention1: Preoperative Stereotactic Radiotherapy in Periampullary Tumors: Patients with periampullary carcinoma who are receiving SBRT will be recruited by the investigator.
Patients will undergo
Sponsors
AIIMS Patna
Eligibility
Inclusion criteria
Inclusion criteria: Literate 18 years or more aged ,ECOG less than 3,Resectable Periampullary malignancy patients with MPD less than 3mm and fit for Radiotherapy
Exclusion criteria
Exclusion criteria: 1.Patients undergoing PD for (suspected) PDAC, chronic pancreatitis, or benign neoplasms (eg, serous cyst) 2.Patients with (a history of) chronic pancreatitis 3.Contraindication for CECT.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantify the incidence of Grade B/C POPF as per ISGPS guidelinesTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess the safety of preoperative SBRT by calculating the incidence of complications(CTCAE grade 3-5 taken as significant) within 30 days post-intervention.Timepoint: 30 days;Feasibility-Ability to deliver the Preoperative Stereotactic Radiotherapy without significant Delays or issues.Timepoint: 30 days;HPE assesement of samples from the pancreatic resection margin and uncinate processTimepoint: 30 days;Pancreatic texture in irradiated and non irradiated tissue determined intraoperatively by the pancreatic surgeon.Timepoint: Intra op | — |
Countries
India
Contacts
Public ContactDrUtpal Anand
AIIMS Patna
Outcome results
None listed