Evaluating the Efficacy of i-PRF as an Adjuvant in Enhancing One-Stage Full-Mouth Disinfection for Stage II and III Periodontitis

Evaluation of the Effectiveness of Injectable Platelet Rich Fibrin (i-PRF) as an Adjuvant to One-Stage Full-Mouth Disinfection in Stage II and III Periodontitis Patients - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088718

Enrollment

Registered

2025-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K056- Periodontal disease, unspecified

Interventions

Intervention1: Injectable Platelet Rich Fibrin (i-PRF): 1 weeks after the Full-mouth Disinfection, i-PRF will be administered subgingivally in all the pockets. Control Intervention1: Full-mouth Disinf

Eligibility

Inclusion criteria

Inclusion criteria: 1. Generalised inter proximal attachment loss involving at least three teeth apart from molars and first incisors. 2. Amount of microbial deposits inconsistent with the severity of periodontal tissue destruction. 3. Patients with a minimum number of 20 teeth. 4. Patients with clinical attachment loss and probing depths (PD) greater than equal to 4mm at 2 sites of a minimum of 12 teeth. 5. The patients included in the study should be systemically healthy. 6. Patients with no history of periodontal therapy in the preceding 6 months or under any antibiotic therapy. 7. Patients motivated to have the therapy and willing to complete the follow-up.

Exclusion criteria

Exclusion criteria: 1. Patients with a known or suspected allergy. 2. Patients who have undergone periodontal therapy in last 6 months. 3. Patients with any systemic disorder affecting periodontal health. 4. Patients with infectious conditions other than periodontitis. 5. Chronic alcoholics. 6. Patients consuming tobacco in any form and smokers. 7. Immuno-compromised and systemically unhealthy patients. 8. Pregnant or lactating females.

Design outcomes

Primary

Measure	Time frame
Use of Injectable Platelet Rich Fibrin (I-PRF) as an adjunct to Full-mouth Disinfection may lead to better outcomesTimepoint: Assessment will be done at baseline, 3 months, 6 months	—

Secondary

Measure	Time frame
N/ATimepoint: N/A	—

Countries

India

Contacts

Public ContactDr Pavan Bajaj

Sharad Pawar Dental College, Datta Meghe Institue of Higher Education and Research

pavbajaj@gmail.com8412045019

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026