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Creating 3D Brain Tumor Models to Explore Treatment Response

Development of high-grade gliomas 3D organoids to understand the role of matrix remodeling and immune cells interaction in therapy resistance - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/06/088709
Enrollment
100
Registered
2025-06-12
Start date
Unknown
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C719- Malignant neoplasm of brain, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

None listed

Eligibility

Inclusion criteria

Inclusion criteria: All diagnosed GBM patients who are undergoing surgical resection.

Exclusion criteria

Exclusion criteria: Minors, pregnant mothers Recurrence GBM cases

Design outcomes

Primary

MeasureTime frame
To develop and utilize advanced three-dimensional organoid models derived from patient samples to better understand the progression and treatment resistance mechanisms of glioblastoma, with a focus on replicating the tumor environment found in the human brain.Timepoint: 12 months from the surgery—

Secondary

MeasureTime frame
To evaluate the response of these models to various therapeutic strategies, including novel delivery systems, with the goal of improving treatment effectiveness.Timepoint: 36 months from the surgery—

Countries

India

Contacts

Public ContactDr Puja Sandbhor

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC)

puja.sandbhor@actrec.gov.in02227405127

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026