A Study on the Effect of Melatonin in Helping Bone Growth After dental implant Placement in Adults

Effect of melatonin on bone formation when placed in the jumping gap in immediate dental implant placement - a case control study - nil

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088681

Enrollment

Registered

2025-06-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K069- Disorder of gingiva and edentulousalveolar ridge, unspecified

Interventions

Intervention1: Melatonin Placement in Jumping gap in immediate dental implant placement: Melatonin will be placed in paste form in the jumping gap which occurs after immediate dental implant placement

Eligibility

Inclusion criteria

Inclusion criteria: Patient having a hopeless tooth indicated for extraction (due to an unrestorable fracture or a carious lesion) requiring immediate dental implant placement. The absence of any active infection/pus discharge and bone dehiscence on buccal wall of tooth socket. Intact socket walls. ASA Grade I and II. Expected jumping gap of = 2mm during implant simulation.

Exclusion criteria

Exclusion criteria: Aggressive periodontitis. ASA Grade III and above. External root resorption. Smoking. Patients who are at high risk of hormonal disturbances, mental disorders, seizures. Pregnant women.

Design outcomes

Secondary

Measure	Time frame
1)To study the clinical and radiological changes occurring after placement of melatonin in jumping gap in immediately placed dental implants. 2)To study the clinical and radiological changes occurring when the jumping gap left unfilled in immediately placed dental implants. 3)To compare the bone formation in the jumping gap when it is filled with melatonin v/s when the gap is left unfilled in immediately placed dental implants. Timepoint: At 0,3 and 6 months postoperatively	—

Measure

Time frame

1)To study the clinical and radiological changes occurring after placement of melatonin in jumping gap in immediately placed dental implants. 2)To study the clinical and radiological changes occurring when the jumping gap left unfilled in immediately placed dental implants. 3)To compare the bone formation in the jumping gap when it is filled with melatonin v/s when the gap is left unfilled in immediately placed dental implants. Timepoint: At 0,3 and 6 months postoperatively

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Primary

Measure	Time frame
1)CLINICAL ASSESSMENT by pink esthetic score to check gingival response and to assess the papilla height. 2)RADIOGRAPHIC ASSESSMENT by IOPA and CBCT to evaluate bone density and marginal bone levelTimepoint: At baseline- radiographic assessment by IOPAR and CBCT At 3 months - radiographic assessment by IOPAR and CBCT and clinical assessment by pink esthetic score At 6 months- radiographic assessment by IOPAR and CBCT and clinical assessment by pink esthetic score	—

Measure

Time frame

1)CLINICAL ASSESSMENT by pink esthetic score to check gingival response and to assess the papilla height. 2)RADIOGRAPHIC ASSESSMENT by IOPA and CBCT to evaluate bone density and marginal bone levelTimepoint: At baseline- radiographic assessment by IOPAR and CBCT At 3 months - radiographic assessment by IOPAR and CBCT and clinical assessment by pink esthetic score At 6 months- radiographic assessment by IOPAR and CBCT and clinical assessment by pink esthetic score

—

Countries

India

Contacts

Public ContactDr Himanshu Bhutani

I.T.S. Dental college, hospital and research centre, greater noida

dr.himanshu@its.edu.in9971772321

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026