A research study to design medical care for critically ill patients in intensive care units to ensure that they receive compassionate, dignified treatment while also providing support to their families.

Multifaceted, Comprehensive, Cost-effective Intervention Package for People with Advanced/Terminal Illnesses needing ICU support, Enabling Appropriate, Ethical, Humane Care, Impacting Resource Utilization and Health Economics (MATHRU) - NIL

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088645

Enrollment

2400

Registered

2025-06-11

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms Health Condition 2: A00-B99- Certain infectious and parasitic diseases Health Condition 3: D50-D89- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism Health Condition 4: E00-E89- Endocrine, nutritional and metabolic diseases Health Condition 5: G00-G99- Diseases of the nervous system Health Condition 6: I00-I99- Diseases of the circulatory system Health Condition 7: J00-J99- Diseases of the respiratory syste

Interventions

Intervention1: Multifaceted Comprehensive Appropriate Care Package (MCACP): MCACP is a structured, evidence-based palliative care intervention designed for ICU patients with advanced and terminal illn

Eligibility

Inclusion criteria

Inclusion criteria: People with Advanced and Terminal illnesses are admitted to ICUs. ICU physicians (senior and junior), nurses (across cadres), and palliative care specialists. Hospital administrators, ethicists, and legal experts. Caregiver/family representatives, especially from lower socioeconomic backgrounds. Types of caregivers we anticipate are - Primary family caregiver (spouse, child), Legal surrogate (next of kin), Professional caregiver (in institutions) Public hospital staff, district-level champions, and voices from tribal/rural communities.

Exclusion criteria

Exclusion criteria: - Patients not diagnosed with advanced or terminal illnesses. - Patients who are receiving care outside ICU settings. - Healthcare professionals who are not directly involved in ICU or palliative care (e.g., outpatient clinic physicians, general practitioners). - Administrators, ethicists, or legal experts who do not have direct hospital or ICU-related experience. - Caregivers who are not actively involved in patient care (e.g., distant relatives or informal acquaintances). - Policy makers or researchers not directly involved in ICU or palliative care management.

Design outcomes

Primary

Measure	Time frame
Co-develop the MCACP intervention. Pilot the MCACP intervention in two ICUs with existing palliative care integration. Expand implementation to four ICUs with existing palliative care access. Extend implementation to four ICUs without existing palliative care access. Modify the intervention at every step in this implementation design framework. Develop a national technical resource hub to facilitate widespread adoption of the MCACP in India.Timepoint: at 18 months, 30 months, 42 months, 60 months	—

Measure

Time frame

Co-develop the MCACP intervention. Pilot the MCACP intervention in two ICUs with existing palliative care integration. Expand implementation to four ICUs with existing palliative care access. Extend implementation to four ICUs without existing palliative care access. Modify the intervention at every step in this implementation design framework. Develop a national technical resource hub to facilitate widespread adoption of the MCACP in India.Timepoint: at 18 months, 30 months, 42 months, 60 months

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactArun Ghoshal

KASTURBA MEDICAL COLLEGE MANIPAL

arun.ghoshal@manipal.edu08202922221

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026