A study on comparing efficacy of nebulized ketamine, betamethasone, and lignocaine for reducing postoperative sore throat, cough, and hoarseness of voice in elective surgery patients under general anaesthesia.

comparative efficacy of nebulized ketamine, betamethasone, and lignocaine for mitigating postoperative sore throat, cough, and hoarseness of voice in elective surgery patients under general anaesthesia - a double blind randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088581

Enrollment

160

Registered

2025-06-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system Health Condition 2: J00-J06- Acute upper respiratory infections

Interventions

Intervention1: NEBULIZATION WITH KETAMINE: ONE GROUP WILL BE GIVEN NEBULIZATION WITH KETAMINE FOR MITIGATING POST OPERATIVE HOARSENESS, COUGH AND SORE THROAT IN ELECTIVE SURGERY PATIENTS UNDER GENERAL

Eligibility

Inclusion criteria

Inclusion criteria: 1.All adult patients aged between 18 to 65 years. 2.Patients with American Society of Anaesthesiologists (ASA) physical status classes I or II. 3.Patients scheduled for elective surgery requiring general anaesthesia with endotracheal intubation. 4.Patients who provided informed consent to participate in the study

Exclusion criteria

Exclusion criteria: 1.All adult patients aged below 18 and above 65 years. 2.Patients with American Society of Anaesthesiologists (ASA) physical status above classes II.

Design outcomes

Primary

Measure	Time frame
1.Assessment of the incidence of postoperative sore throat, cough, and hoarseness of voice within the first 24 hours following surgery. 2.Comparison of the severity of postoperative sore throat, cough, and hoarseness of voice among patients receiving nebulised ketamine, betamethasone, or lignocaine 3.Haemodynamic variables (HR, BP, SpO2) will be monitored, compared before nebulisation before intubation and post extubationTimepoint: 18 months	—

Measure

Time frame

1.Assessment of the incidence of postoperative sore throat, cough, and hoarseness of voice within the first 24 hours following surgery. 2.Comparison of the severity of postoperative sore throat, cough, and hoarseness of voice among patients receiving nebulised ketamine, betamethasone, or lignocaine 3.Haemodynamic variables (HR, BP, SpO2) will be monitored, compared before nebulisation before intubation and post extubationTimepoint: 18 months

—

Secondary

Measure	Time frame
1.Assessment of the duration (in hours) of postoperative sore throat, cough, and hoarseness of voice among patients in each intervention group. 2.Identification and documentation of any adverse effects related to the administration of nebulised ketamine, betamethasone, or lignocaine. 3.Assessment of patient satisfaction with postoperative throat symptoms and overall comfort using a standardized satisfaction survey or questionnaire. 4.Comparison of patient satisfaction levels between the nebulised ketamine, betamethasone, and lignocaine intervention groups to identify differences in perceived effectiveness and comfort. Timepoint: 18 months	—

Measure

Time frame

1.Assessment of the duration (in hours) of postoperative sore throat, cough, and hoarseness of voice among patients in each intervention group. 2.Identification and documentation of any adverse effects related to the administration of nebulised ketamine, betamethasone, or lignocaine. 3.Assessment of patient satisfaction with postoperative throat symptoms and overall comfort using a standardized satisfaction survey or questionnaire. 4.Comparison of patient satisfaction levels between the nebulised ketamine, betamethasone, and lignocaine intervention groups to identify differences in perceived effectiveness and comfort. Timepoint: 18 months

—

Countries

India

Contacts

Public ContactNAZREEN BANU J

All India Institute Of Medical Sciences, Nagpur

dravinash@aiimsnagpur.edu.in9999596845

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026