Health Condition 1: A415- Sepsis due to other Gram-negativeorganisms
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Continuous infusion Group: Eligible patients with septic shock will be identified and recruited from intensive care unit (ICU). After obtaining informed consent,
Sponsors
Dr.kunchala anand
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1.The patient aged more than 18 years 2.The patient has a documented GNB infection with carbapenem resistance and synergy positive 3.The patient initiated on Ceftazidime avibactam with or without aztreonam to treat the episode of infection 4.Eligible participants expected to remain in the ICU for atleast 48 hours
Exclusion criteria
Exclusion criteria: Exclusion Criteria 1 Patient aged less than 18 years 2 The patient has received Ceftazidime avibactam and aztreonam for more than 24 hours during current infectious episode 3 The patient is known or suspected to be pregnant 4 The patient has a known allergy to beta Lactam Antibiotics 5 Chronic Renal Failure on Maintenance Dialysis 6 Lack Of Consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical success on day 14Timepoint: Clinical success is defined as Patient s survival status, Hemodynamic stability systolic blood pressure more than 90 mm Hg without requiring vasopressor support, Enhancement in SOFA score Specifically, for a baseline SOFA score more than 3, a minimum 30 percent improvement in score is necessary, while for a SOFA score less than 3, a reduction of at least 1 point is required, Patients not meeting all these success criteria will be categorized as experiencing clinical failure by day 14. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 Microbiological relapse 2 Microbiological failure. 3 Vasopressors free days 4 Mechanical ventilator free days 5 ICU free days 6 ICU mortality 7 In-hospital mortality Timepoint: Outcomes will be assessed on day 7 & day 14 Microbiological failure: Characterized by the recurrence of bacteria phenotypically identical to the initial isolates on or after day 7. Microbiological relapse : Defined as recurrence of bacteria phenotypically identical to the initial isolate after a previous negative culture within 14 days. | — |
Countries
India
Contacts
Public ContactDR RENUKA MK
sri ramachandra medical education and research
Outcome results
None listed