Comparison of efficacy of Moringa leaves gel with tretinoin in treatment of oral leukoplakia

Comparison of efficacy of Moringa Oleifera leaves extract gel (2%) with Tretinoin cream (0.1%) in the treatment of Oral Leukoplakia: A Randomized Controlled Clinical Trial - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/06/088561

Enrollment

Registered

2025-06-10

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K132- Leukoplakia and other disturbancesof oral epithelium, including tongue

Interventions

Intervention1: moringa oleifera leaves extracts 2%: a natural chemopreventive agent made from moringa leaves ( drumstick ) rich in flavanoids and anti-oxidants with better safety profiles and lesser

Eligibility

Inclusion criteria

Inclusion criteria: patients clinically diagnosed with homogenous leukoplakia. Both male and female patients of age 21-70 years and are willing to participate in the study.

Exclusion criteria

Exclusion criteria: Patients clinically diagnosed with non-homogenous Leukoplakia Patients under treatment for chronic systemic diseases. Patients of age above 70 years. Patients under treatment for other OPMDs. Pregnant and lactating females.

Design outcomes

Primary

Measure	Time frame
regression in the size the lesion will be measuredTimepoint: at base line, 1 month, 2 month and 3 months	—

Secondary

Measure	Time frame
reduction in the hyperkeratosis and dysplasia of the epitheliumTimepoint: 18 months	—

Countries

India

Contacts

Public ContactNidadavole Shrijitha

government dental college and hospital,vijayawada

ramesh99inbox@gmail.com6300044525

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026